04 November

Carbon Nanostructures for the Ébola Virus

Friday 04 November 2016, 12:00pm

ICN2 Seminar Hall, ICN2 Building, UAB

Prof Nazario Martín - Full professor of Organic Chemistry at the University Complutense of Madrid and vice-director of the Institute for Advanced Studies in Nanoscience of Madrid (IMDEA-Nanoscience). 

Short abstract: We have shown that fullerene sugar balls, namely hexakis-adducts of [60]fullerene appended with 12, 24 or 36 mannose moieties, act as strong inhibitors for DC-SIGN in an Ebola infection assay model. Furthermore, a drastic increase in the inhibition process to the subnanomolar scale has been observed when the size and mannoses´ number are increased in the new tridecafullerenes endowed with 120 mannose units decorating the periphery of the molecule. In this presentation, the different nanocarbons platforms used for the multivalent presentation of carbohydrates for an artificial Ebola virus infection model will be discussed.

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