11 October

Improved synthesis routes and coating approaches of anisotropic magnetite nanoparticles for theranostics

Friday 11 October 2019, 12:30pm

ICN2 Seminar Hall, ICN2 Building, UAB

PhD: Javier Muro

Directors: ICREA Research Prof. Josep Nogués, Group Leader, and Dr Alejandro Gómez, Postdoctoral Researcher at Magnetic Nanostructures Group at ICN2

Short Abstract: Although modern therapies against cancer have improved dramatically in recent years, they still show multiple side effects which can affect the life quality of patients. Therefore, more specific treatments are needed. Hyperthermia has long been proposed as an alternative way to treat tumours, as cancer cells are more sensitive to high temperatures than the healthy ones. Magnetic nanoparticles can be used to locally generate heat via magnetic induction under the application of an alternating magnetic field, which could be exploited to induce local cell death on tumours with minimal side effects. In addition, they can be used for diagnosis, as they can enhance the contrast in Magnetic Resonance Imaging (MRI).

In this thesis we have optimized the magnetic properties of biocompatible magnetite particles by tuning their morphology (nanocubes and nanorods), as it has been described that shape anisotropy should enhance their performance in both magnetic hyperthermia and MRI. In addition, we have shown that these particles can be used also as photothermal agents, as they can generate heat under the irradiation of near infrared lasers. Their improved capability as a theranostic agents and their high biocompatibility have been confirmed by in-vitro experiments. The results highlight the potential of these anisotropic structures for biomedical applications.